Anti-BK virus activity of nucleoside analogs.

نویسندگان

  • Parmjeet Randhawa
  • Jiri Zemlicka
  • Andreas Sauerbrei
  • Chris Meier
  • Karl Y Hostetler
  • James R Beadle
  • Noush Afarin Farasati
  • Yuchen Huang
  • Matthews Bradley
چکیده

Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 4  شماره 

صفحات  -

تاریخ انتشار 2008